diff --git a/codex-rs/cli/src/debug_sandbox.rs b/codex-rs/cli/src/debug_sandbox.rs
index f4282343b..852af4d21 100644
--- a/codex-rs/cli/src/debug_sandbox.rs
+++ b/codex-rs/cli/src/debug_sandbox.rs
@@ -42,12 +42,14 @@ pub async fn run_command_under_seatbelt(
     codex_linux_sandbox_exe: Option<PathBuf>,
 ) -> anyhow::Result<()> {
     let SeatbeltCommand {
+        permissions_profile,
         allow_unix_sockets,
         log_denials,
         config_overrides,
         command,
     } = command;
     run_command_under_sandbox(
+        permissions_profile,
         command,
         config_overrides,
         codex_linux_sandbox_exe,
@@ -71,10 +73,12 @@ pub async fn run_command_under_landlock(
     codex_linux_sandbox_exe: Option<PathBuf>,
 ) -> anyhow::Result<()> {
     let LandlockCommand {
+        permissions_profile,
         config_overrides,
         command,
     } = command;
     run_command_under_sandbox(
+        permissions_profile,
         command,
         config_overrides,
         codex_linux_sandbox_exe,
@@ -90,10 +94,12 @@ pub async fn run_command_under_windows(
     codex_linux_sandbox_exe: Option<PathBuf>,
 ) -> anyhow::Result<()> {
     let WindowsCommand {
+        permissions_profile,
         config_overrides,
         command,
     } = command;
     run_command_under_sandbox(
+        permissions_profile,
         command,
         config_overrides,
         codex_linux_sandbox_exe,
@@ -112,6 +118,7 @@ enum SandboxType {
 }
 
 async fn run_command_under_sandbox(
+    permissions_profile: Option<String>,
     command: Vec<String>,
     config_overrides: CliConfigOverrides,
     codex_linux_sandbox_exe: Option<PathBuf>,
@@ -125,6 +132,7 @@ async fn run_command_under_sandbox(
             .parse_overrides()
             .map_err(anyhow::Error::msg)?,
         codex_linux_sandbox_exe,
+        permissions_profile,
     )
     .await?;
 
@@ -563,20 +571,30 @@ mod windows_stdio_bridge {
 async fn load_debug_sandbox_config(
     cli_overrides: Vec<(String, TomlValue)>,
     codex_linux_sandbox_exe: Option<PathBuf>,
+    permissions_profile: Option<String>,
 ) -> anyhow::Result<Config> {
     load_debug_sandbox_config_with_codex_home(
         cli_overrides,
         codex_linux_sandbox_exe,
+        permissions_profile,
         /*codex_home*/ None,
     )
     .await
 }
 
 async fn load_debug_sandbox_config_with_codex_home(
-    cli_overrides: Vec<(String, TomlValue)>,
+    mut cli_overrides: Vec<(String, TomlValue)>,
     codex_linux_sandbox_exe: Option<PathBuf>,
+    permissions_profile: Option<String>,
     codex_home: Option<PathBuf>,
 ) -> anyhow::Result<Config> {
+    if let Some(permissions_profile) = permissions_profile {
+        cli_overrides.push((
+            "default_permissions".to_string(),
+            TomlValue::String(permissions_profile),
+        ));
+    }
+
     // For legacy configs, `codex sandbox` historically defaulted to read-only
     // instead of inheriting ambient `sandbox_mode` settings from user/system
     // config. Keep that behavior unless this invocation explicitly passes a
@@ -698,6 +716,7 @@ mod tests {
         let config = load_debug_sandbox_config_with_codex_home(
             Vec::new(),
             /*codex_linux_sandbox_exe*/ None,
+            /*permissions_profile*/ None,
             Some(codex_home_path),
         )
         .await?;
@@ -748,6 +767,7 @@ mod tests {
         let config = load_debug_sandbox_config_with_codex_home(
             cli_overrides,
             /*codex_linux_sandbox_exe*/ None,
+            /*permissions_profile*/ None,
             Some(codex_home_path),
         )
         .await?;
@@ -797,6 +817,7 @@ mod tests {
         let config = load_debug_sandbox_config_with_codex_home(
             Vec::new(),
             /*codex_linux_sandbox_exe*/ None,
+            /*permissions_profile*/ None,
             Some(codex_home_path),
         )
         .await?;
@@ -809,4 +830,88 @@ mod tests {
 
         Ok(())
     }
+
+    #[tokio::test]
+    async fn debug_sandbox_honors_explicit_builtin_permission_profile() -> anyhow::Result<()> {
+        let codex_home = TempDir::new()?;
+
+        let config = load_debug_sandbox_config_with_codex_home(
+            Vec::new(),
+            /*codex_linux_sandbox_exe*/ None,
+            Some(":workspace".to_string()),
+            Some(codex_home.path().to_path_buf()),
+        )
+        .await?;
+
+        assert_eq!(
+            config.permissions.file_system_sandbox_policy(),
+            codex_protocol::models::PermissionProfile::workspace_write()
+                .file_system_sandbox_policy()
+        );
+
+        Ok(())
+    }
+
+    #[tokio::test]
+    async fn explicit_permission_profile_overrides_active_profile_sandbox_mode()
+    -> anyhow::Result<()> {
+        let codex_home = TempDir::new()?;
+        std::fs::write(
+            codex_home.path().join("config.toml"),
+            "profile = \"legacy\"\n\
+             \n\
+             [profiles.legacy]\n\
+             sandbox_mode = \"danger-full-access\"\n",
+        )?;
+
+        let config = load_debug_sandbox_config_with_codex_home(
+            Vec::new(),
+            /*codex_linux_sandbox_exe*/ None,
+            Some(":workspace".to_string()),
+            Some(codex_home.path().to_path_buf()),
+        )
+        .await?;
+
+        assert_eq!(
+            config.permissions.file_system_sandbox_policy(),
+            codex_protocol::models::PermissionProfile::workspace_write()
+                .file_system_sandbox_policy()
+        );
+
+        Ok(())
+    }
+
+    #[tokio::test]
+    async fn debug_sandbox_honors_explicit_named_permission_profile() -> anyhow::Result<()> {
+        let codex_home = TempDir::new()?;
+        let sandbox_paths = TempDir::new()?;
+        let docs = sandbox_paths.path().join("docs");
+        let private = docs.join("private");
+        write_permissions_profile_config(&codex_home, &docs, &private)?;
+
+        let config = load_debug_sandbox_config_with_codex_home(
+            Vec::new(),
+            /*codex_linux_sandbox_exe*/ None,
+            Some("limited-read-test".to_string()),
+            Some(codex_home.path().to_path_buf()),
+        )
+        .await?;
+
+        let expected = build_debug_sandbox_config(
+            vec![(
+                "default_permissions".to_string(),
+                TomlValue::String("limited-read-test".to_string()),
+            )],
+            ConfigOverrides::default(),
+            Some(codex_home.path().to_path_buf()),
+        )
+        .await?;
+
+        assert_eq!(
+            config.permissions.file_system_sandbox_policy(),
+            expected.permissions.file_system_sandbox_policy()
+        );
+
+        Ok(())
+    }
 }
diff --git a/codex-rs/cli/src/lib.rs b/codex-rs/cli/src/lib.rs
index 1f3968545..f78afa0fa 100644
--- a/codex-rs/cli/src/lib.rs
+++ b/codex-rs/cli/src/lib.rs
@@ -21,6 +21,10 @@ pub use login::run_logout;
 
 #[derive(Debug, Parser)]
 pub struct SeatbeltCommand {
+    /// Named permissions profile to apply from the active configuration stack.
+    #[arg(long = "permissions-profile", value_name = "NAME")]
+    pub permissions_profile: Option<String>,
+
     /// Allow the sandboxed command to bind/connect AF_UNIX sockets rooted at this path. Relative paths are resolved against the current directory. Repeat to allow multiple paths.
     #[arg(long = "allow-unix-socket", value_parser = parse_allow_unix_socket_path)]
     pub allow_unix_sockets: Vec<AbsolutePathBuf>,
@@ -44,6 +48,10 @@ fn parse_allow_unix_socket_path(raw: &str) -> Result<AbsolutePathBuf, String> {
 
 #[derive(Debug, Parser)]
 pub struct LandlockCommand {
+    /// Named permissions profile to apply from the active configuration stack.
+    #[arg(long = "permissions-profile", value_name = "NAME")]
+    pub permissions_profile: Option<String>,
+
     #[clap(skip)]
     pub config_overrides: CliConfigOverrides,
 
@@ -54,6 +62,10 @@ pub struct LandlockCommand {
 
 #[derive(Debug, Parser)]
 pub struct WindowsCommand {
+    /// Named permissions profile to apply from the active configuration stack.
+    #[arg(long = "permissions-profile", value_name = "NAME")]
+    pub permissions_profile: Option<String>,
+
     #[clap(skip)]
     pub config_overrides: CliConfigOverrides,
 
diff --git a/codex-rs/cli/src/main.rs b/codex-rs/cli/src/main.rs
index 01e44fd8c..ab33d9f94 100644
--- a/codex-rs/cli/src/main.rs
+++ b/codex-rs/cli/src/main.rs
@@ -1922,6 +1922,30 @@ mod tests {
         assert!(matches!(cli.subcommand, Some(Subcommand::Update)));
     }
 
+    #[test]
+    fn sandbox_macos_parses_permissions_profile() {
+        let cli = MultitoolCli::try_parse_from([
+            "codex",
+            "sandbox",
+            "macos",
+            "--permissions-profile",
+            ":workspace",
+            "--",
+            "echo",
+        ])
+        .expect("parse");
+
+        let Some(Subcommand::Sandbox(SandboxArgs {
+            cmd: SandboxCommand::Macos(command),
+        })) = cli.subcommand
+        else {
+            panic!("expected sandbox macos command");
+        };
+
+        assert_eq!(command.permissions_profile.as_deref(), Some(":workspace"));
+        assert_eq!(command.command, vec!["echo"]);
+    }
+
     #[test]
     fn plugin_marketplace_remove_parses_under_plugin() {
         let cli =
diff --git a/codex-rs/core/src/config/mod.rs b/codex-rs/core/src/config/mod.rs
index 7fce4833d..fe9a8e433 100644
--- a/codex-rs/core/src/config/mod.rs
+++ b/codex-rs/core/src/config/mod.rs
@@ -8,6 +8,7 @@ use crate::windows_sandbox::WindowsSandboxLevelExt;
 use crate::windows_sandbox::resolve_windows_sandbox_mode;
 use crate::windows_sandbox::resolve_windows_sandbox_private_desktop;
 use codex_config::CloudRequirementsLoader;
+use codex_config::ConfigLayerSource;
 use codex_config::ConfigLayerStack;
 use codex_config::ConfigLayerStackOrdering;
 use codex_config::ConfigRequirements;
@@ -1531,7 +1532,30 @@ fn resolve_permission_config_syntax(
     sandbox_mode_override: Option<SandboxMode>,
     profile_sandbox_mode: Option<SandboxMode>,
 ) -> Option<PermissionConfigSyntax> {
-    if sandbox_mode_override.is_some() || profile_sandbox_mode.is_some() {
+    if sandbox_mode_override.is_some() {
+        return Some(PermissionConfigSyntax::Legacy);
+    }
+
+    let session_flags_select_profiles = config_layer_stack
+        .get_layers(
+            ConfigLayerStackOrdering::HighestPrecedenceFirst,
+            /*include_disabled*/ false,
+        )
+        .into_iter()
+        .find(|layer| matches!(layer.name, ConfigLayerSource::SessionFlags))
+        .and_then(|layer| {
+            layer
+                .config
+                .clone()
+                .try_into::<PermissionSelectionToml>()
+                .ok()
+        })
+        .is_some_and(|selection| selection.default_permissions.is_some());
+    if session_flags_select_profiles {
+        return Some(PermissionConfigSyntax::Profiles);
+    }
+
+    if profile_sandbox_mode.is_some() {
         return Some(PermissionConfigSyntax::Legacy);
     }